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Meridia® (sibutramine hydrochloride monohydrate) is the first FDA approved medication of its class for the treatment of weight loss and weight maintenance. Sibutramine is an equipotent serotonin and norepinephrine reuptake inhibitor (SNRI), which means it has an equal effect on serotonin (a brain neurotransmitter which generally promotes a calming feeling) and norepinephrine (a stimulant). Research indicates that these brain chemicals have an effect on appetite and satiety. Meridia® is available in 5 mg, 10 mg, and 15 mg capsules (see photo). The recommended starting dose is 10 mg which may be increased to 15 mg if the 10 mg capsule is ineffective. The 5 mg capsule can be used as an adjunct to the 10 mg dose; it is not intended to be used as a starting dose.
