Spectroscopy methods

See this at: spectroscopymethods....| Added on 06/28/06

Ye ability to observe solid-state alteration in a formulation ir spectroscopy depends on the analytical technique used to characterize the sample. Scientists use differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), Charles... See more

Ye ability to observe solid-state alteration in a formulation ir spectroscopy depends on the analytical technique used to characterize the sample. Scientists use differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), Charles Fourier transform infrared (FT-IR), and Raman spectrum analysis as well as X-ray pulverisation diffraction (XRD) to canvass pharmaceuticals in the solid state. Each technique provides information about a sample.DSC and TGA qualify the physical properties of a specific solid (e.g., the melting point or ye hydration state) from ye active agent pharmaceutical ingredient (API) just have limited public utility in the study of solid-state changes inch a preparation compared with spectroscopic methods. FOOT-IR and Raman spectroscopy furnish insight into the individual components in a preparation and, inch some cases, ar extremely sensitive to solid-state modification. X-ray methods, either single crystal or pulverisation diffraction, bring out... See less