Using cells obtained from cancer-stricken mice, scientists from the Howard Hughes Medical Institute (HHMI) at Stanford University have showed that reducing production of sterols — chemicals, such as cholesterol, that are a vital...
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Using cells obtained from cancer-stricken mice, scientists from the Howard Hughes Medical Institute (HHMI) at Stanford University have showed that reducing production of sterols — chemicals, such as cholesterol, that are a vital part of cell membranes — can prevent the rapid growth of medulloblastoma cells in culture. Medulloblastoma is the most common form of malignant childhood brain cancer. The cancer is due to a breakdown in normal communication between cells. The findings of the new study, which was published in the May 15, 2006, issue of the Proceedings of the National Academy of Sciences (PNAS), are important because they trace molecules connected to sterol metabolism that have powerful effects on medulloblastoma cells. The new work potentially paves the way for novel treatments, said senior researcher Matthew P. Scott, a Howard Hughes Medical Institute (HHMI) investigator at Stanford University.
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