Absorption Drugs are usually administered either orally or intravenously. When drugs are administered orally, absorption is much more complex than when administered intravenously. The drug has to bypass a number of barriers before...
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Absorption Drugs are usually administered either orally or intravenously. When drugs are administered orally, absorption is much more complex than when administered intravenously. The drug has to bypass a number of barriers before it can get into the blood stream and do its thing. First, it must get past the acid in the stomach. Second, it must over come bacteria in the small intestines. Third, it must survive changes in the small intestines. Finally, it must survive the metabolism process in the liver known as the first pass effect. During the first pass effect, blood travels to the liver as part of a filtering system where enzymes in the liver metabolize or change part of a drug before it enters the bloodstream. Enzymes are proteins that change drugs in the body and also help biochemical reactions occur as discussed above. Drugs are absorbed faster when administered intravenously. They enter the blood stream immediately, and aren't absorbed like when taken orally. They bypass being metabolized by the liver, skipping the first pass effect. Distribution The distribution process simply involves the transportation of drug throughout the blood stream. Metabolism Metabolism is the chemical change a drug goes through in the body. The major place where this takes place is in the liver. This is where most people run into problems with steroid usage that I will get into shortly. Excretion Excretion is simply the removal of drug from the body. The kidneys are responsible for most drug excretion through the urine. Some drugs such as steroids are excreted by the liver. Drugs are also excreted through the breast, skin and lungs. You will see how drug excretion directly relates to the adverse effects of steroids. Side Effects The amount of drug that enters the body will determine the two effects we discussed early, the therapeutic effect and the side effect, also called toxic effect. Therapeutic effects, the desirable effects, are not always dose related. This means that 400 milligrams of aspirin may work as well as 800 milligrams to cure a headache. A doctor's goal is to administer the lowest effective dose because side effects are dose related: The higher the dose, the greater the side effects. If 400 milligrams of a drug will cure your headache, why take 800 milligrams? Anabolic steroids are very toxic to the liver where they are metabolized and excreted. You better believe that the side effects from steroids are dose related. There are many bodybuilders who take more steroids than they need to see the desired results. There is no need to take five tablets when one is just as effective. The biggest risk you take with steroids is damage to the liver. The liver is the most versatile and amazing organ in the body. Every minute, about three pints of blood pass through the liver. At any time, the liver contains about 10% of all the blood in the body. It helps the blood digest food substances and excretes waste materials, toxins, steroids, estrogen, and other hormones. It also stores sugar and glycogen, iron, copper, vitamin A, several of the B vitamins, and Vitamin D and also produces proteins. Without a properly working liver, you are in big trouble! When steroids, such as Anadrol 50, are taken orally, they need to be detoxified by the liver through the metabolism process discussed above. The liver works harder to eliminate poisonous substances and toxins produced by steroids. As a result, hepatitis or inflammation of the liver can occur. Hepatitis can easily lead to cirrhosis of the liver, a condition of progressive scarring. Cirrhosis is a disease so severe, that it kills all the liver cells, causing liver failure. Steroids can also disease the heart. The blood carries basically two types of cholesterol, HDL (high density lipoproteins) the good cholesterol and LDL (low density lipoproteins) the bad cholesterol. The good cholesterol helps get rid of the bad cholesterol. The bad cholesterol is responsible for clogging arteries. Lower levels of HDL and higher levels of LDL directly correlate to heart attacks. Steroids increase the
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It resembles the drug Winstrol V. Like Winstrol, it is said to be very ... Winstrol V (stanozolol) is a very popular steroid among bodybuilders known for ...
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